News / Lack of cargo sees carriers forced into last-minute voyage cancellations

first_img Despite ocean carriers discounting container spot rates from Asia this week, there was still insufficient cargo to sustain the already reduced alliance service networks.Maersk and MSC were obliged to cancel this week’s 2M AE7/Swan loop from China to North Europe at the last minute after they were unable to secure enough cargo.The 19,472 teu MSC Rifaiya commenced its loading programme in Ningbo, China on Monday, but rather than despatch the ship to Europe less than half-full The Loadstar understands it was decided to anchor the vessel.The 2M partners said today they would also blank the sailing of the AE15 loop next week, with the 13,050 teu MSC Ariane scheduled to start loading in Shanghai on Monday.This follows the announcement in the week by the 2M of a further void sailings to the Mediterranean and on the transpacific, together with a number of other westbound cancellations by the Ocean and THE alliances.The Shanghai Containerized Freight Index (SCFI) was not published again this week as the impact of the coronavirus outbreak in China shuttered many offices and businesses, with some not resuming until 17 February.However, the Ningbo Containerized Freight Index (NCFI) did publish today, showing spot rate erosion across all its main components.For North Europe, the NCFI recorded a 7.6% decline on the week to $782 per teu, while for west Mediterranean ports ,there was a fall of 5.6% to $793 per teu.In its commentary, the NCFI referred to the market position for Europe as “seriously insufficient”.Meanwhile, UK-based forwarder Westbound Logistics has advised customers of a rate reduction in the pipeline valid from 15 February, but also warned that there could be upward pressure on rates next month as carriers deal with the backlog of frustrated orders when production and the logistics industry begins to return to some form of normality.Westbound urged its customers to plan early “to avoid as much panic-buying into over-inflated prices”.Other forwarders are putting out similar messages to their clients and endeavouring to assist them to navigate the significant supply chain disruption from the extended manufacturing closures in China.Twill, Maersk’s in-house digital arm, has advised its clients to delay cargo as long as possible, and consider using air or rail for urgent shipments.It said: “We know that demand for shipments following the extended break will be very high and this might impact short-term prices. The more you can delay the shipments the cheaper it will be.”On the transpacific tradelane, the Freightos Baltic Exchange (FBX) index for the US west coast stood at $1,509 per 40ft, edging down a surprisingly modest 1% on the week. For US east coast ports, the FBX ticked up 1% on the week to take the spot rate to $2,858 per 40ft.It said: “China-US freight rates have yet to show the impact of the crisis, likely because carriers have announced record blank sailings through early March, even before the outbreak, and because rates are already quite depressed, down 26% compared with last year.” By Mike Wackett 07/02/2020last_img read more

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Trump, claiming progress in lowering drug prices, tells Congress ‘we must do more’

first_img By Ike Swetlitz Feb. 5, 2019 Reprints Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. Politics Trump, claiming progress in lowering drug prices, tells Congress ‘we must do more’ What is it? What’s included? STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. GET STARTED President Donald Trump delivers his State of the Union address Tuesday. Andrew Harnik/AP Log In | Learn More Unlock this article by subscribing to STAT+ and enjoy your first 30 days free! GET STARTED WASHINGTON — In his State of the Union address Tuesday, President Trump touted his administration’s work to reduce the price of prescription drugs and called on Congress to take further action.But his remarks on the issue were light on specifics — and in some cases, misleading. Tags Congressdrug pricinggovernment agenciespolicyWhite Houselast_img read more

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Range of options to choose from Portarlington Further Education and Training Centre

first_img 2020 U-15 ‘B’ glory for Ballyroan-Abbey following six point win over Killeshin Here are all of Wednesday’s Laois GAA results WhatsApp Facebook Facebook GAA GAA GAA TAGSLOETBPortarlington Further Education Applications are now being accepted for September courses in Portarlington Further Education and Training Centre – and you can find out more at their Open Morning this Friday, March 8, from 9.30am to 12.30pm. Portarlington Further Education is part of the Laois and Offaly Education and Training Board and is based on Bracklone Street in Portarlington.They offer full-time QQI courses and part-time component awards.Return to learning with streams in Office Skills, Healthcare and ChildcareOffice Administration Level 5Early Childcare and Education Modules Level 5Healthcare Support Level 5Administration Practice Level 6Accounting Technician Certificate (Full-time only)Accounting Technician Diploma (Full-time only)For further information you can check out www.portarlingtonaec.ie or email [email protected] ALSO – Check out the dedicated jobs section on LaoisToday.ie Kelly and Farrell lead the way as St Joseph’s claim 2020 U-15 glory Range of options to choose from Portarlington Further Education and Training Centre WhatsApp Twitter Twitter Previous articleLaois Third Level hosting Open Morning on Friday, March 8Next articleBrakes put on Portlaoise land disposal LaoisToday Reporter By LaoisToday Reporter – 4th March 2019 Pinterest Home Sponsored Range of options to choose from Portarlington Further Education and Training Centre Sponsored Pinterest RELATED ARTICLESMORE FROM AUTHORlast_img read more

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Extra support to help veterans secure employment

first_imgExtra support to help veterans secure employment Minister for Veterans’ AffairsVETERANS will benefit from specialised one-on-one support to help them find employment or change careers through the Support for Employment (SFE) program launched today.Minister for Veterans’ Affairs and Minister for Defence Personnel Darren Chester said the SFE program built on the Government’s improvements to transition and employment support made in recent years and would deliver further pre-and-post employment assistance.“Our ADF personnel have a great range of skills, expertise and a positive attitude to see them succeed in the civilian workplace. Simply put, hiring a veteran is good for business,” Mr Chester said.“In order to ensure our veterans are putting their best foot forward, the SFE will provide up to 10 hours of one-on-one support across a range of employment services, including resume writing, job seeking support, interview preparation and workplace adjustment.“This will better support veterans to secure appropriate employment or change careers and is another step in the right direction as part of the Government’s commitment to ensuring a successful transition for ADF members.“To complement the SFE program, we are continuing to build an understanding in the broader community of the valuable skills that veterans bring to the workforce and how valuable they can be to an organisation.”The SFE program is open to veterans who have transitioned from the permanent ADF between 12 months and up to five years ago and are unemployed, consider themselves to be under-employed, seeking assistance to change careers, or require support to adjust to the civilian workplace. The SFE program is part of the Prime Minister’s Veterans’ Employment Program, which supports veterans’ employment and the promotion of their skills in the civilian workforce. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:ADF, business, community, Defence, employment, Government, interview, Minister, Prime Minister, veterans, workforcelast_img read more

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Halfway for Rozelle Interchange tunnelling

first_imgHalfway for Rozelle Interchange tunnelling Construction of Australia’s biggest road infrastructure project has reached another major milestone, with Rozelle Interchange tunnelling passing the half way mark.Premier Gladys Berejiklian said more than 9,000 workers have worked on this stage of the WestConnex project, which also includes the Iron Cove Link.“The NSW Government is committed to investing in major road infrastructure projects because we know improving our road network makes a real difference to people’s lives, while also providing much needed local jobs at a time when we need them most,” Ms Berejiklian said.“The Rozelle Interchange is the missing link in the WestConnex Project and, along with the M4-M5 tunnels, will provide connections to the City West Link and the future Western Harbour Tunnel, while also bypassing Victoria Road.”Minister for Transport and Roads Andrew Constance said while tunnelling continues underground, plans to transform the old Rozelle Rail Yards into a park are coming to life.“We know construction of the Rozelle Interchange is having a big impact on local residents and we thank them for their patience,” Mr Constance said.“When the project is finished, the new Rozelle Parklands will have green fields for leisure activities, a boardwalk, picnic areas, play equipment, and new pedestrian and cycling paths.“The 10 hectares of public parkland and open space will transform life in the Inner West, and will be a great legacy for Rozelle locals and the wider Sydney community.”Other project facts:24 kilometres of tunnelling, including three levels of tunnels in some parts. 12 kilometres of tunnelling has been dug out so far.Expected to use 640,000 cubic metres of concrete and 32,000 tonnes of Australian steel.The Rozelle Parklands’ Urban Design Landscape Plan was on public display last year. Submissions have been collated and the UDLP is currently with DPIE.The Rozelle Parklands Working Group has started meeting formally to determine the optimal uses for the park. The Rozelle Interchange is on schedule to be completed by late 2023.Gladys BerejiklianPremierAndrew ConstanceMinister for Transport and Roads /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Australia, Australian, Berejiklian, community, cycling, Gladys, Gladys Berejiklian, Government, infrastructure, Liberal Party, Minister, missing, NSW, nswpol, Pedestrian, Sydney, Transport, Victorialast_img read more

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Strengthening confidence-building and dialogue mechanisms between regional and sub-regional organisations

first_imgStrengthening confidence-building and dialogue mechanisms between regional and sub-regional organisations Thank you, Secretary-General Guterres and Mr Ban and all of the briefers for the poignant reminders of the challenges we collectively face.As we all recognise, conflict has a devastating impact. We know it hits hardest amongst the poorest and indeed the most vulnerable.By the World Bank’s reckoning, by 2030, two thirds of the world’s extreme poor could be affected by a fragility, conflict and violence.The Council’s agenda, sadly, is a tragic testimony. In the last two weeks alone, we have discussed conflicts in Yemen, in Mali, in Syria and the Great Lakes region, amongst others.So, Mr President, we welcome the adoption today of a presidential statement under your leadership. We hope it will serve to strengthen confidence-building measures and, indeed, dialogue mechanisms with the regional, sub-regional and importantly, civil society organisations on whom peace processes so deeply depend.I would like to highlight three ways that we believe we can strengthen the vital role of these organisations.First, regional and sub-regional organisations can restore trust between conflict-affected communities. In particular, the work of the OSCE High Commissioner on national minorities has reduced tensions and prevented conflict across the OSCE region. As regional organisations develop their technical capacity, they should seek to follow this very example. And we should seek to boost their willingness to use confidence-building measures as and when it’s required.Secondly, confidence-building and dialogue must be absolutely part of a broader strategy coordinated through the good offices of the United Nations.We recognise the unique role of ASEAN of addressing the crisis in Myanmar. The UK further welcomes ASEAN’s readiness to support positive and constructive efforts. And therefore we look forward to the close UN-ASEAN cooperation to solve the conflict and serve those who are suffering, those who are in need.We also applaud the 2017 United Nations African Union Joint Framework for Enhanced Partnership in Peace and Security. This was indeed instrumental in the 2019 peace agreement between the Government of the Central African Republic and 14 armed groups. And we call upon all political actors to remain committed directly to it.Thirdly, regional bodies need to include civil society organisations in a meaningful capacity at all levels of dialogue. If we are truly to build inclusive and enduring peace, civil society bodies should be – have to be – pivotal in all aspects of conflict prevention and importantly, also in conflict resolution.As has been said by others, including my good friend, the Foreign Minister of Ireland, it’s important that women are central to peacemaking. In particular, regional women’s networks, such as ASEAN Women for Peace Registry and the African Union’s FEMWISE Africa, are vital actors in the pursuit of a lasting and sustainable peace.The United Kingdom, I assure you, is absolutely committed to protecting and promoting women peace builders, and we are proud to have supported the International Civil Society Action Network’s Protection Framework. I urge others to support and implement its expert and effective recommendations.On our shared path to peace, we need this more open and inclusive approach for a stronger and more coherent international response. The nature of conflict has changed. Increasingly, we see conflicts that are intrastate in nature, which have the potential to destabilise peace and security on a global level. We also see how marginalisation and human rights violations can totally and utterly isolate communities and indeed perpetrate violence.To tackle these conflicts’ driving forces, we must and we need to combine our humanitarian, development and peacebuilding efforts. The Peacebuilding Commission is absolutely at the heart of this, and we commend the Peacebuilding Fund’s support, which builds trust amongst communities, because ultimately, where national and regional efforts fail, it is the Security Council that has primary responsibility for both international peace and international security.We do that best when we have a clear view. The United Kingdom supports regular and coordinated early warning capabilities, which help the Council to prevent escalation. Regional organisations can strengthen that capability by sharing early warning assessments and bringing emerging situations to the Council’s direct attention. Accurate and timely information needs to be coupled with effective early engagement and support at community, state, regional or continental level.And where prevention activities fail, or there is no regional consensus, it is this Council that should lead the international community not just to discuss, to debate, but to act. The United Kingdom stands ready to support regional and subregional organisations as they continue to strengthen the confidence building and dialogue efforts.It is only by mobilising all the tools at our collective disposal, Mr President, that we can avoid the escalation of violence and secure the lasting, sustainable peace that we all desire.Thank you, Mr President. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Africa, African, ASEAN, Central, Central African Republic, Government, Ireland, Mali, Myanmar, Security Council, Syria, UK, UK Government, United Kingdom, United Nations, World Bank, Yemenlast_img read more

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Power of Investments for African Tourism Highlighted as INVESTOUR Returns

first_imgPower of Investments for African Tourism Highlighted as INVESTOUR Returns UNWTOThe importance of unlocking the potential of investments for growing African tourism was highlighted as leaders from across the sector met virtually for the 2021 edition of INVESTOUR. Held during the FITUR International Tourism Trade Fair, the 12th edition of the Forum for Tourism Investment and Business (INVESTOUR) united government representatives alongside experts from international organizations and from the private sector. Once again, the event was co-organized by Casa Africa, FITUR and the World Tourism Organization (UNWTO), building on the latter’s 2030 Agenda for Africa.This year, the focus was on the importance of promoting sustainable investments to help the sector recover from the impacts of the COVID-19 pandemic. On the agenda were the role of public-private partnerships, building resilience, and promoting innovation at every step of the broad tourism value chain.A roundtable discussion on “Revitalizing Tourism Post-COVID-19”, explored ways to identify and reach new markets and develop new tourism products. Contributing were Mouhamed Faouzou, Technical Advisor to the Minister of Tourism and Air Transport of Senegal, Dr. Alfonso Vegara, Founder and President of Fundación Metrópoli, and Alberto Virella Gomes, Ambassador-at-Large for the Africa Plan, Ministry of Foreign Affairs for Senegal. This was followed by a series of investment webinars led by UNWTO experts, with a special focus on sustainability and capacity development.In a message to the INVESTOR delegates, Secretary-General Zurab Pololikashvili stressed the importance of government-initiated Ease of Doing Business reforms and invited delegates to join UNWTO for its 64th Commission for Africa and the 2nd UNWTO Global Tourism Investment Forum in Africa, both to be held in Cabo Verde this September. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Africa, African, Air transport, Commission, Foreign Affairs, Government, innovation, Investment, President, resilience, Secretary-General, Senegal, sustainability, sustainable, Transport, UNWTOlast_img read more

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Bentley debuts new midrange Bentayga S

first_img First Look: 2022 Lexus NX The sport-cute’s looks have been softened, but its powertrains and infotainment offerings have been sharpened RELATED First Look: 2021 Bentley Bentayga First Drive: 2020 Bentley Bentayga Hybrid The real changes happen under the surface, at the suspension level. There’s a new Bentley Dynamic Ride control that uses a 48-volt system to electronically apply up to 959 pound-feet of torque to counteract body roll. Bentley says this is the first of its kind in the industry, and it’s standard on the Bentayga S. We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. COMMENTSSHARE YOUR THOUGHTS Trending in Canada See More Videos Trending Videos Bentley has revealed its latest creation: the Bentayga S, a sporty version of the high-riding SUV. The Bentayga S will sit in between the regular Bentayga and the Bentayga Speed, offering a happy medium between comfort and excitement.Under the hood of the Bentayga S is the venerable 4.0-litre V8, fitted with two turbochargers. No upgrades were added to the engine, so it makes the same 542 horsepower and 568 pound-feet of torque, which helps with its 0-100 km/h time of just 4.5 seconds, and top speed of 180 miles per hour.While the engine remains the same, the exterior receives some subtle visual cues to distinguish the S from the regular Bentayga, including unique 22” wheels, larger spoiler, black door mirrors, gloss black side sills and lower bumpers, and black tailpipes. PlayThe Rolls-Royce Boat Tail may be the most expensive new car everPlay3 common new car problems (and how to prevent them) | Maintenance Advice | Driving.caPlayFinal 5 Minivan Contenders | Driving.caPlay2021 Volvo XC90 Recharge | Ministry of Interior Affairs | Driving.caPlayThe 2022 Ford F-150 Lightning is a new take on Canada’s fave truck | Driving.caPlayBuying a used Toyota Tundra? Check these 5 things first | Used Truck Advice | Driving.caPlayCanada’s most efficient trucks in 2021 | Driving.caPlay3 ways to make night driving safer and more comfortable | Advice | Driving.caPlayDriving into the Future: Sustainability and Innovation in tomorrow’s cars | Driving.ca virtual panelPlayThese spy shots get us an early glimpse of some future models | Driving.ca advertisement The suspension is also 15 percent stiffer than a standard Bentayga, thanks to increased pressure in the dampers. A new Sport driving mode also enhances the experience with improved steering feel and a more responsive throttle, while a free-flow exhaust and torque vectoring round out the upgrades. The Rolls-Royce Boat Tail may be the most expensive new car ever RELATED TAGSBentaygaBentleySUVLuxuryFamily VehiclesLuxury VehiclesNew Vehicles ‹ Previous Next ›last_img read more

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CU-Boulder Unity Walk To Help Bring Campus Community Together

first_img Published: Sept. 20, 2001 Share Share via TwitterShare via FacebookShare via LinkedInShare via E-mail Seeking to promote unity in a time of tragedy, the University of Colorado at Boulder’s Undergraduate Academy will sponsor a unity and remembrance walk at noon on Tuesday, Sept. 25, to mark the two-week anniversary of the terrorist attacks on America. The event will convene with a brief program on the steps of Norlin Library on the CU-Boulder quadrangle. Participants will then make a short loop through campus, taking about an hour to complete the walk. The walk has two goals, according to Kathy King, a senior at CU-Boulder and a member of the Undergraduate Academy. “First, it is a tribute to everyone who lost their life as a result of the terrorist attacks,” she said. “The walk also will be a symbol of solidarity throughout the university community, and will send the message that CU will not tolerate violence against any members of our community.” Several incidents of hateful activity have been reported on the university campus since the events of Sept. 11, and CU-Boulder administrators have taken a number of steps to prevent further incidents. The Undergraduate Academy has extended a special invitation to all of the religious groups on the CU-Boulder campus, including the Muslim Student Alliance and Hillel, the Jewish student organization, who will participate in the walk. The entire university community is invited to attend the Unity Walk. “Our goal is to have as diverse a group as possible, to show that we will not allow these terrible acts to divide our community,” said King. The Undergraduate Academy was created to continue the education of exceptionally talented and intellectually lively students outside the classroom, build a sense of intellectual community among participants and help prepare them for post-graduation opportunities. Undergraduate Academy students have demonstrated that they care about ideas and learning, are concerned about contemporary issues and problems and that they want to make the most of their undergraduate years, said King. For more information call (303) 735-6802 or visit the Web site at http://www.Colorado.EDU/AcademicAffairs/UndergraduateEducation/UA.last_img read more

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Pharma companies need to limit the presence of nitrosamines in human medicines: EMA

first_imgPharma companies need to limit the presence of nitrosamines in human medicines: EMA WHO tri-regional policy dialogue seeks solutions to challenges facing international mobility of health professionals By EH News Bureau on July 10, 2020 Heartfulness group of organisations launches ‘Healthcare by Heartfulness’ COVID care app blood pressure medicinescancerEUEuropean CommissionEuropean Medicines Agencyhuman carcinogensmedicinesnitrosamines Share Phoenix Business Consulting invests in telehealth platform Healpha Related Posts Menopause to become the next game-changer in global femtech solutions industry by 2025 Patients should generally not be exposed to a lifetime risk of cancer exceeding 1 in 100,000 from nitrosamines in their medicinesEuropean Medicines Agency’s (EMA) human medicines committee (CHMP) has issued an opinion requiring companies to take measures to limit the presence of nitrosamines in human medicines as much as possible and to ensure levels of these impurities do not exceed set limits.The measures will ensure that nitrosamines are either not present or are present below levels identified to protect public health.Pharma companies will be required to have appropriate control strategies to prevent or limit the presence of these impurities and, where necessary, improve their manufacturing processes.Companies will also have to evaluate the risk of nitrosamines being present in medicines and carry out appropriate tests if a risk is identified.Nitrosamines are classified as probable human carcinogens (substances that could cause cancer). The limits for nitrosamines in medicines have been set using internationally agreed standards (ICH M7(R1)) based on lifetime exposure. Patients should generally not be exposed to a lifetime risk of cancer exceeding 1 in 100,000 from nitrosamines in their medicines.Detailed information for companies, including timelines, will soon be available in updated documents on the EMA’s nitrosamines webpage. In the meantime, companies should continue to follow current instructions.EU regulators first became aware of nitrosamines in medicines in mid-2018 and took regulatory actions, including recalling medicines and stopping the use of active substances from certain manufacturers. A subsequent CHMP review of sartan blood pressure medicines in 2019 led to new requirements for the manufacture of sartans, while its review of ranitidine recommended in 2020 an EU-wide suspension of ranitidine medicines.In addition, a recently concluded exercise to draw lessons from the presence of nitrosamines in sartans has made a number of recommendation to help prevent the presence of impurities in medicines. The recommendations complement the latest requirements from CHMP.In drawing up the requirements, EMA worked closely with national authorities, the European Directorate for the Quality of Medicines & Healthcare and international partner agencies. Authorities in the EU, including the European Commission, will work together to ensure that the same measures are taken for medicines irrespective of how they were authorised.Authorities in the EU will continue to take all necessary measures to protect patients and reassure them about the quality of their medicines. Comments (0) Cancer News Patient Safety Read Article Indraprastha Apollo Hospitals releases first “Comprehensive Textbook of COVID-19” MaxiVision Eye Hospitals launches “Mucormycosis Early Detection Centre” The missing informal workers in India’s vaccine story Add Commentlast_img read more

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