Sarepta gene therapy for Duchenne muscular dystrophy stumbles with failed study outcome

first_imgBiotech Tags biotechnologydrug developmentgene therapySTAT+ Adam Feuerstein @adamfeuerstein About the Author Reprints Senior Writer, Biotech Adam is STAT’s national biotech columnist, reporting on the intersection of biotech and Wall Street. He’s also a co-host of “The Readout LOUD” podcast. What’s included? By Adam Feuerstein Jan. 7, 2021 Reprints Sarepta gene therapy for Duchenne muscular dystrophy stumbles with failed study outcome Log In | Learn More center_img Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. GET STARTED Sarepta Therapeutics on Thursday announced mixed results from the first randomized clinical trial of its gene therapy for Duchenne muscular dystrophy, raising questions about the path forward for the one-time, potentially curative treatment.A single infusion of the treatment, called SRP-9001, produced large increases in a crucial muscle protein typically missing in children born with Duchenne. But the increases failed to coincide with statistically significant improvements in muscle function for all patients after one year. Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+. First 30 days free. GET STARTED STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. [email protected] Ruby Wallau for STAT What is it?last_img read more

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Deputies search for answers in October murder of Naples man

first_imgAdvertisementAnyone with information is asked to contact SWFL Crime Stoppers at 1-800-780-8477 or to submit a tip here. Tipsters could be eligible for a cash reward. COLLIER COUNTY, Fla. – A Naples man was murdered on Oct. 3, 2020 — and deputies are still searching for answers. Steven Douglas, 36, was found shot to death in his car at 2669 River Reach Drive, according to the Collier County Sheriff’s Office. Neighbors said they heard gun shots before deputies arrived. Douglas was in the driver’s seat of a white 2006 Buick Rendezvous, which had struck a tree in the parking lot, deputies said. Douglas’ family decided to release his name to the public to help further the investigation, according to CCSO. Sea turtle caught on camera nesting on Naples beach June 16, 2021 AdvertisementTags: Collier County Sheriff’s Officenaples RELATEDTOPICS Advertisement Collier school resource officers teach kids how to fish on first day of “Summerfest” June 16, 2021center_img Naples soldier facing charges for wife’s murder June 16, 2021 AdvertisementRecommended ArticlesBrie Larson Reportedly Replacing Robert Downey Jr. As The Face Of The MCURead more81 commentsGal Gadot Reportedly Being Recast As Wonder Woman For The FlashRead more29 comments Advertisement AdvertisementDC Young Fly knocks out heckler (video) – Rolling OutRead more6 comments’Mortal Kombat’ Exceeded Expectations Says WarnerMedia ExecutiveRead more2 commentsDo You Remember Bob’s Big Boy?Read more1 commentsKISS Front Man Paul Stanley Reveals This Is The End Of KISS As A Touring Band, For RealRead more1 comments Study ranks Naples as best beach town in America to live June 16, 2021last_img read more

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Sprott profit down 90% in second quarter

Management fees during the quarter were $28.1 million, a decrease of 24.6% compared with a year ago. Assets under management slipped to $8.5 billion as at June 30, compared to $9.3 billion as at June 30, 2011 and $9.7 billion as at Mar. 31, 2012. Assets under administration dropped to $3.8 billion as at June 30, compared to $5.3 billion a year earlier. Losses from investment losses totaled $4 million for the quarter, essentially the same as the quarter ended June 30, 2011. Commission revenues for the quarter were $2.1 million compared to $4.9 million a year earlier. “Our investment performance was disappointing through the first six months of the year and this negatively impacted our financial results,” Peter Grosskopf, CEO of Sprott Inc. After the end of the quarter, Sprott finalized the acquisition of Toscana Capital Corp. and closed the acquisition of Flatiron Capital Management Partners. “We continue to build our business and recently completed the acquisitions of Flatiron and the Toscana Companies,” Grosskopf added. “Together, these transactions further diversify our investment capabilities and product offerings through the addition of top convertible arbitrage and energy yield specialists, allowing us to launch value-added yield products that are currently in high demand,” he said. Sportt (TSX:SII) currently operates through four business units: Sprott Asset Management LP, Sprott Private Wealth LP, Sprott Consulting LP, and Sprott U.S. Holdings Inc. Share this article and your comments with peers on social media Canaccord reports record revenues, drops proposal to acquire RF Capital Laurentian Bank reports $53.1M profit in Q2, beats expectations Canadian banks to focus on growth, spending and buybacks after strong second quarter Facebook LinkedIn Twitter Related news Keywords EarningsCompanies Sprott Inc. IE Staff Disappointing investment results led to sharply lower second quarter earnings for Toronto-based Sprott Inc., the company said Thursday. Net income for the three months ended June 30 was $0.7 million, or $0.00 per share, a decrease of 90.2% from $7.5 million, or $0.04 per share, in the comparable quarter of 2011. read more

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More Effective Strategies Needed to Target Men to Become Leaders – Says PM Golding

first_imgMore Effective Strategies Needed to Target Men to Become Leaders – Says PM Golding UncategorizedFebruary 16, 2008 FacebookTwitterWhatsAppEmail Prime Minister Bruce Golding is of the view that more effective means of convincing and attracting men in the society, who have never been able to understand their role as fathers, leaders in the home, church and community, will have to be implemented on a national basis in order to effect meaningful change. Mr. Golding said it is almost impossible to establish shared values and goals because as a nation ‘ we have lost a sense of who we are, a sense of right and wrong and the understanding of how we relate to each other’.Mr. Golding was speaking this morning ( Feb 16) at day two of the inaugural interdenominational men’s conference titled ‘COVENANT- Jamaica’s men on a mission’, at the Jamaica Conference Centre in downtown Kingston.The two day Conference got underway yesterday ( Feb 15) with an official opening ceremony at the Mona Visitors Lodge, UWI, Mona. The conference was conceived by conference Chairman, Courtney Campbell and various church leaders, to call Jamaican men to action to assume an appropriate leadership role in society, within the home, workplace, church and community.Mr Golding told the fair-seized audience of mostly middle-age, middle class men that, ‘We are culturally a pluralistic society so reaching these men will not be achieved by a ‘one-size fit all’ strategy. You will have to use all different means of reaching them . These men cannot be redeemed unless they can be reached’. He noted that in a recent chat with entertainer Bounty Killa, the artiste expressed the view that he wanted to give back to society and to use the positive messages in his music to help young men who have failed in their roles as leaders in the home. Mr. Golding advised that individuals such as entertainers may well have to be enlisted to play a role because they have an audience which is loyal to them and which will listen to them.He also advised that another approach may well be to follow the examples set by the investment clubs which appear to have mastered the art of building a pyramid of followers and supporters. ‘ If you can bring more people to buy into this endeavour and it becomes the fashionable thing to do, you will be creating a whole army of followers and with this kind of inspiration, we can create a new crusade and begin to see some positive movement towards changing the mindset of our men to become more responsible fathers and better leaders’, Mr. Golding said.Mr. Golding extended an invitation to the organizers of the conference to join forces with a coordinating committee which was established recently and which is being anchored out of Jamaica House, under the leadership of Rev Al Miller. He said this committee has been mandated to come up with a national programme that will incorporate the work of all the churches, non-government organizations, community based associations and service clubs. He urged the conference organizers to become involved in the process noting that this umbrella organization would help to consolidate this broad effort to try and make Jamaica the wonderful place God intended it to be.The conference this morning (Feb 16) heard presentations by visiting guest speaker, Hon Alvin Curling- Co-Chair of Ontario’s Roots of Youth Violence Secretariat, former Member Provincial Parliament for Ontario Canada, and who’s also Jamaican. Panel discussions were led by several Jamaican Christian businessmen and pastors including Dr Henley Morgan, Rev Al Miller Mr Reynold Scott, Mr Courtney Campbell, and Mr. Robert Levy . RelatedMore Effective Strategies Needed to Target Men to Become Leaders – Says PM Golding RelatedMore Effective Strategies Needed to Target Men to Become Leaders – Says PM Goldingcenter_img Advertisements RelatedMore Effective Strategies Needed to Target Men to Become Leaders – Says PM Goldinglast_img read more

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Minister Smith Seeks Further Medical Advice

first_imgRelatedMinister Smith Seeks Further Medical Advice RelatedMinister Smith Seeks Further Medical Advice Advertisements RelatedMinister Smith Seeks Further Medical Advicecenter_img Minister Smith Seeks Further Medical Advice UncategorizedMay 26, 2008 FacebookTwitterWhatsAppEmail Minister of Mining and Telecommunications the Honourable Derrick Smith left the island this afternoon (May 25) for the United States.Mr. Smith, who has been absent from official duties since last month following a minor surgical procedure, is seeking further medical advice in the United States.He is expected to return to Jamaica within ten days.And the Acting Prime Minister Dr. Kenneth Baugh says the Cabinet is looking forward to Mr. Smith’s return to office at the earliest possible time.last_img

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Birthright Programme Being Renewed

first_imgRelatedBirthright Programme Being Renewed Birthright Programme Being Renewed UncategorizedDecember 26, 2008 FacebookTwitterWhatsAppEmail The GraceKennedy Jamaica Birthright Programme, which gives college level Jamaican students living overseas a chance to revisit their cultural roots during the summer recess, is being renewed by the company for 2009.This programme, which was established five years ago, provides a unique opportunity for the students to participate in an all expense paid internship programme in Jamaica, while connecting with their ancestral roots.“The programme was started, in part, to reconnect second and third generation Jamaicans to their proud Jamaican heritage, and has scored very well,” according to the GraceKennedy/Western Union representative for the Northeast United States, Garfield Comrie.Interested students must complete entry requirements on line at: www.gracekennedy.com, on or before December 31, 2008. Candidates must be between 18 and 30 years of age, with a grade point average (GPA) of 3.0 or higher.Selected candidates will work, on rotation, within the GraceKennedy Group, offering them mentorship, hands on and practical experience in a wide variety of industries. They will be further exposed to the Jamaican heritage, through visits and field trips to historic sites, and cultural packages.“As always, the GraceKennedy Jamaica Birthright Programme will give successful candidates a well-rounded Jamaican experience,” noted Mr. Comrie, adding that the programme is an excellent way to learn and enjoy, while earning.The Programme Committee can be contacted vie e-mail at: [email protected] RelatedBirthright Programme Being Renewedcenter_img Advertisements RelatedBirthright Programme Being Renewedlast_img read more

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Sugar Workers to Receive Payments Within a Month…PM Golding

first_imgAdvertisements Sugar Workers to Receive Payments Within a Month…PM Golding AgricultureMay 28, 2009 RelatedSugar Workers to Receive Payments Within a Month…PM Golding FacebookTwitterWhatsAppEmail Prime Minister Bruce Golding has assured redundant sugar workers that within a month they will be receiving payments due to them.Last night (May 27) he told listeners on his call-in radio programme Jamaica House Live, “We gave an undertaking that redundancy payments will be made in June. Both the Ministry of Finance and the Ministry of Agriculture confirmed to me a week ago that plans are in place for redundancy payments to be made in the first half of the month.”The Prime Minister also noted that re-employment of the displaced workers will depend to a great extent on the privatization efforts.“The Sugar divestment team is in negotiations with parties who indicated interest in the tender,” he said; and he promised that he would continue to keep the nation abreast of developments in this important sector.center_img RelatedSugar Workers to Receive Payments Within a Month…PM Golding RelatedSugar Workers to Receive Payments Within a Month…PM Goldinglast_img read more

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Government of Canada contributes CAD 1 million to WFP to support national school meal programme and boost local farming

first_imgGovernment of Canada contributes CAD 1 million to WFP to support national school meal programme and boost local farming WFPCOLOMBO – The United Nations World Food Programme (WFP) and the Government of Sri Lanka welcome a funding of CAD 1 million (LKR 151 million) from Global Affairs Canada to help smallholder farmers cultivate nutritious crops for the National School Meal Programme. Responding to the impacts of Covid-19, the Home Grown School Feeding project will provide nutritious and safe school meals to vulnerable primary school children by linking the National School Meal Programme with local smallholder farmers. The project will benefit an estimated 1,700 female farmers and 170,000 children in several districts across the Northern, Eastern and North Central provinces.The Home Grown School Feeding project is an innovative approach and the first of its kind in Sri Lanka. It is designed to boost local economy and improve the nutritional status of communities in regions with poor nutrition standards and high levels of poverty. By purchasing produce for the school meals from local smallholder farmers residing in the vicinity of the schools, the project creates a predictable outlet for farmers and a stable income while stimulating local production of nutrient-dense crops. The funding from Canada will benefit an estimated 170,000 primary grade school children who receive free meals in school, by ensuring that the meals provided are nutritious, diverse, fresh and culturally appropriate. The meals are also an incentive for families to send their children, especially girls, to school.The project focuses on empowering women and contributing to gender equality. The smallholder farmers selected for the project will be primarily women, mostly mothers of the school children, from some of the poorest households who have been hard hit by Covid-19’s impact on food systems. The project includes community engagement and behaviour change campaigns to address disproportionate workload and care responsibilities placed on women, while enhancing nutrition education and promoting better eating habits. The project will also assist in building resilience of farmers to recurring climate shocks by boosting productivity of family farms.“Canada is pleased to re-engage with WFP in supporting the Government of Sri Lanka to improve nutrition among school children and food security in Sri Lanka, both of which were negatively impacted by Covid-19,” says Canadian High Commissioner, David McKinnon. “This is great for Sri Lanka’s agricultural self-sufficiency and for girls’ retention in schools, especially in these Covid times.”“Sri Lanka welcomes Canada’s support to supplement the current nutrition programme for school children,” says Honourable Piyal Nishantha De Silva, State Minister of Women and Child Development, Pre School and Primary Education, School Infrastructure and School Services. “We invest considerable resources in the National School Meal Programme and we welcome WFP’s assistance to make it more effective and sustainable. This programme will also boost local economies and help alleviate poverty among rural communities.”“Covid-19 has highlighted vulnerabilities within our food systems and calls for urgent interventions to strengthen the path of food from farm to table,” says Andrea Berardo, Deputy Country Director of WFP Sri Lanka. “Part of the solution lies in creating a formal structure to place smallholder farmers at the centre of food systems, ensuring that regular supply meets regular demand. By harnessing WFP’s expertise in food and nutrition, the Home Grown School Feeding project creates diverse benefits to improve the livelihoods and nutrition standards among entire communities.”WFP has been supporting the National School Meal Programme since 2003 to improve nutrition standards among school children. Canada has been one of the largest contributors to Sri Lanka’s School Meal Programme, providing funds in excess of CAD 10 Million (LKR 1.5 Billion) to WFP from 2003 to 2017, benefitting over 450,000 children. This latest funding from the Government of Canada enables WFP to augment its support to the programme and contributes towards the achievement of Sustainable Development Goal 2: Zero Hunger.Photo caption: Two farmers from Manmunai West, Batticaloa who are currently engaged in WFP’s resilience building project which promotes sustainable agriculture. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Agriculture, Canada, Central, Commissioner, community engagement, Eastern, gender equality, Government, infrastructure, production, resilience, Sri Lanka, sustainable, United Nations, WFP, womenlast_img read more

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New $15m mental health facility to deliver better services

first_imgNew $15m mental health facility to deliver better services Young South Australians with severe mental health problems will have access to a brand new inpatient facility at the Women’s and Children’s Hospital (WCH), as part of the Marshall Liberal Government’s vision to build better health services.The $15m Mallee Ward will replace the former Boylan Ward at the WCH and is run by the Child and Adolescent Mental Health Service (CAMHS).Minister for Health and Wellbeing Stephen Wade said the new state-of-the-art facility forms part of the Marshall Liberal Government’s vital $50 million upgrades to the WCH.“The Mallee Ward is the only designated psychiatric inpatient facility for children and adolescents in South Australia. It houses a range of new spaces and features that will help clinicians to be able to continue to provide the highest level of care to children and young people experiencing mental distress and crisis,” Minister Wade said.“As the major hospital for some of the state’s most vulnerable people, it is essential the WCH continues to operate at the highest standard while planning continues for the new hospital. In the meantime we will not neglect those who need services now.“A significant level of consultation and planning went in to the design and construction of this new ward, ensuring that young people with both acute and significant mental health needs can receive the care they need.“This includes the exciting new feature of a courtyard, giving consumers access to an outdoor area for the first time, and providing a space for a number of important therapeutic activities to assist with their treatment.”The new Mallee Ward will also include a high dependency / low stimulus area, individual patient rooms with ensuites, consult spaces, sensory rooms, larger recreation spaces, as well as a staff-led kitchen and laundry.Children and young people will be given an e-bracelet that provides them with access to their room only. Areas such as the kitchen and computer spaces are completely lockable to block unsupervised access.Women’s and Children’s Health Network Child and Adolescent Mental Health Services Clinical Director, Dr Mohammed Usman, said consumers and current inpatients played a big role in many of the ward’s design features.“The design of the Mallee Ward incorporates a great level of attention to detail to enhance the care and comfort of patients, including natural light and calming colours, as well as safety features on doors, bedding and bedside storage,” said Dr Usman.“The new ward has been designed to allow for a four-bed High Dependency/Low Stimulus Unit (HD/LS-U) separate from the rest of the ward, to provide more acute treatment for patients who require more acute care. It can be opened or closed to meet patient and staff needs.”Boylan Inpatient Unit Nursing Unit Manager, Kendall Lounder, said the upgrade would significantly benefit the young patients, allowing the ward to offer a larger number of wrap-around therapies and services.“The Ward provides specialised care and support for children and adolescents with acute and often complex mental health problems, and this significant upgrade will allow us to provide increased care to our vulnerable young people,” Ms Lounder said.“The incorporation of the courtyard into the new space will allow for us to provide therapeutic gardening. Young people will be able to grow and care for produce and use it in cooking activities as well.“The larger exercise space and equipment will also provide an area for the activity therapist to hold group sessions.“The healing and supportive environment will enhance the treatment and therapies offered, with the patient’s dignity and care at its centre.” /Public News. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:adolescent, AusPol, Australia, director, environment, Government, health, health facility, health services, Kendall, mental health, SA Government, South Australia, treatment, Ward, wellbeing, women, younglast_img read more

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2019 Lexus LC500 Inspiration Series is very yellow

first_img PlayThe Rolls-Royce Boat Tail may be the most expensive new car everPlay3 common new car problems (and how to prevent them) | Maintenance Advice | Driving.caPlayFinal 5 Minivan Contenders | Driving.caPlay2021 Volvo XC90 Recharge | Ministry of Interior Affairs | Driving.caPlayThe 2022 Ford F-150 Lightning is a new take on Canada’s fave truck | Driving.caPlayBuying a used Toyota Tundra? Check these 5 things first | Used Truck Advice | Driving.caPlayCanada’s most efficient trucks in 2021 | Driving.caPlay3 ways to make night driving safer and more comfortable | Advice | Driving.caPlayDriving into the Future: Sustainability and Innovation in tomorrow’s cars | Driving.ca virtual panelPlayThese spy shots get us an early glimpse of some future models | Driving.ca ‹ Previous Next › See More Videos Trending Videos Lexus is only going to build 100 of the LC500 Inspiration Series, and pricing starts at US$106,210. Look for availability to start in April, although Canadian pricing and availability have not been announced just yet. advertisement We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. At last year’s Pebble Beach Concours d’Elegance, Lexus introduced a bright yellow LC500 concept, with carbon fibre bits and a customized interior. Now, that car is heading to production as a special edition model.The LC500 Inspiration Series, as Lexus calls it, will make its debut production-car debut at the 2019 Chicago Auto Show next week, featuring almost all of the upgrades from the concept. The car is finished in Electric Flare Yellow and features a carbon fibre roof and grille. Inside, yellow Alcantara door inserts add a pop of colour, while carbon fibre sills denote this is a special edition LC.One thing that has changed from the concept is the 21-inch wheels. They’re still the same size, but now sport a different five-spoke pattern. The engine, however, remains unchainged: The 5.0-litre naturally aspirated V8 produces 471 horsepower, sent to the rear wheels via a 10-speed automatic. Zero-to-100 km/h still happens in just 4.5 seconds. RELATED TAGSCoupeLuxuryLuxury VehiclesNew Vehicles Buy It! Princess Diana’s humble little 1981 Ford Escort is up for auction An engagement gift from Prince Charles, the car is being sold by a Princess Di “superfan” Trending in Canada The Rolls-Royce Boat Tail may be the most expensive new car ever COMMENTSSHARE YOUR THOUGHTSlast_img read more

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